orotate phosphoribosyltransferase การใช้

Orotate phosphoribosyltransferase ( PRPP transferase ) catalyzes the net reaction yielding orotidine monophosphate ( OMP ):
These agents achieve this by inhibiting the enzyme dihydropyrimidine dehydrogenase ( uracil / gimeracil ) or orotate phosphoribosyltransferase ( oteracil ).
Oteracil mainly stays in the gut because of its low permeability, where it reduces the production of 5-FU by blocking the enzyme orotate phosphoribosyltransferase.
This bifunctional enzyme has two main domains, an orotate phosphoribosyltransferase ( OPRTase, ) subunit and an orotidine-5-phosphate decarboxylase ( ODCase, ) subunit.